Thiol isomerases negatively regulate the cellular shedding activity of ADAM17
نویسندگان
چکیده
منابع مشابه
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17.
ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of proligands for cellular receptors. Many regulatory pathways affect the ADAM17 sheddase activity, but the mechanisms for the activation are still not clear. We have utilized a cell-based ADAM17 assay to show that thiol isomerases, specifi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2010
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20100179